Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 1.432


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOSL1chr11_-_656678580.783.7e-06Click!
JUNBchr19_+_129022950.359.1e-02Click!
JUNDchr19_-_183924130.331.0e-01Click!
FOSchr14_+_75745480-0.321.2e-01Click!
FOSBchr19_+_45971249-0.096.8e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74606222 20.501 NM_000584
IL8
interleukin 8
chr1_-_169703178 19.131 NM_000450
SELE
selectin E
chr1_-_95007139 13.642 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr9_-_123688352 13.039 TRAF1
TNF receptor-associated factor 1
chr15_+_89182038 11.597 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_183155393 11.447 LAMC2
laminin, gamma 2
chr21_+_26934440 10.483 MIR155HG
MIR155 host gene (non-protein coding)
chr1_+_183155173 8.749 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr12_-_49259549 8.246 NM_014470
RND1
Rho family GTPase 1
chr1_-_153521717 8.181 NM_002960
S100A3
S100 calcium binding protein A3
chr1_+_183155361 7.660 LAMC2
laminin, gamma 2
chr2_+_152214105 7.633 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr11_-_8739398 7.574 ST5
suppression of tumorigenicity 5
chr6_+_138188352 7.197 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr17_+_21191347 6.627 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr11_-_102668892 5.526 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_-_102668822 5.507 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr18_+_61554938 5.434 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr4_-_76957139 5.282 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr3_+_11178778 4.803 NM_001098213
HRH1
histamine receptor H1
chr11_-_65430427 4.784 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr15_+_67458492 4.599 NM_001145104
SMAD3
SMAD family member 3
chr8_+_86157693 4.549 NM_198584
CA13
carbonic anhydrase XIII
chr4_-_122085475 4.549 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr6_-_44233499 4.502 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr6_-_44233244 4.494 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr10_-_6019880 4.490 NM_001243539
IL15RA
interleukin 15 receptor, alpha
chr10_-_6019454 4.429 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr11_-_102651321 4.351 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr16_+_57662301 4.245 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr11_-_65430214 4.239 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr18_+_55888838 4.182 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_103191795 4.149 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr18_+_55888799 4.141 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_+_86158004 4.139 CA13
carbonic anhydrase XIII
chr6_+_83072922 4.100 NM_006670
TPBG
trophoblast glycoprotein
chr21_-_36421586 4.059 NM_001754
RUNX1
runt-related transcription factor 1
chr1_-_173176314 3.994 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr7_+_28448970 3.805 LOC401317
uncharacterized LOC401317
chr12_+_78225068 3.653 NM_014903
NAV3
neuron navigator 3
chr9_+_5510544 3.634 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr1_-_209824641 3.602 NM_001017402
LAMB3
laminin, beta 3
chr13_+_97794050 3.576 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_28725597 3.570 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr21_-_36421630 3.525 RUNX1
runt-related transcription factor 1
chr17_+_74380943 3.452 SPHK1
sphingosine kinase 1
chr1_+_212738675 3.428 NM_001030287
ATF3
activating transcription factor 3
chr19_-_47735858 3.408 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr21_+_43619798 3.402 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr17_+_74381186 3.337 NM_001142602
SPHK1
sphingosine kinase 1
chr17_+_74381419 3.325 SPHK1
sphingosine kinase 1
chr1_-_89488412 3.280 NM_018284
GBP3
guanylate binding protein 3
chr17_+_79651035 3.227 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr5_+_35856990 3.216 NM_002185
IL7R
interleukin 7 receptor
chr17_+_79651042 3.213 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr8_+_126442557 3.172 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr10_+_30723050 3.117 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr2_+_201997687 3.065 NM_001202518
CFLAR
CASP8 and FADD-like apoptosis regulator
chr18_+_55888750 3.063 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_74920329 3.063


chr17_+_79650961 2.989 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr5_-_121413906 2.987 LOX
lysyl oxidase
chr10_+_104155431 2.936 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chrX_-_154563735 2.912 NM_001289
CLIC2
chloride intracellular channel 2
chr5_-_121413967 2.878 LOX
lysyl oxidase
chr10_+_30722856 2.870 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr2_+_161993465 2.822 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr10_+_91092238 2.818 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr5_-_121414011 2.803 NM_002317
LOX
lysyl oxidase
chr17_-_39296702 2.727 NM_030976
KRTAP4-6
keratin associated protein 4-6
chr17_+_79651072 2.672 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr19_-_44174497 2.661 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr15_+_67418053 2.657 NM_001145102
SMAD3
SMAD family member 3
chr13_+_97928414 2.550 MBNL2
muscleblind-like 2 (Drosophila)
chr14_-_91710851 2.446 NM_001177676
GPR68
G protein-coupled receptor 68
chr7_+_150065330 2.439 REPIN1
replication initiator 1
chr16_+_56642477 2.413 NM_005953
MT2A
metallothionein 2A
chr14_+_55168831 2.399 SAMD4A
sterile alpha motif domain containing 4A
chr13_+_97928196 2.387 MBNL2
muscleblind-like 2 (Drosophila)
chr16_-_48266181 2.383 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr11_-_65667809 2.380 FOSL1
FOS-like antigen 1
chr21_-_35899046 2.369 NM_203418
RCAN1
regulator of calcineurin 1
chr5_+_179247841 2.367 NM_003900
SQSTM1
sequestosome 1
chr11_-_65667858 2.366 FOSL1
FOS-like antigen 1
chr1_+_156084458 2.320 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr3_-_187454247 2.297 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr11_+_35639734 2.288 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr11_-_65667860 2.280 NM_005438
FOSL1
FOS-like antigen 1
chr20_-_43977023 2.272 NM_002999
SDC4
syndecan 4
chr9_-_134585107 2.266 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr2_+_103035148 2.231 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_-_10419786 2.180 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr12_-_323255 2.138 NM_001122848
NM_001206931
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr19_-_44174271 2.103 PLAUR
plasminogen activator, urokinase receptor
chr19_+_10381516 2.088 NM_000201
ICAM1
intercellular adhesion molecule 1
chr5_-_150466696 2.046 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr18_+_61637262 2.009 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr6_-_134496833 2.008 SGK1
serum/glucocorticoid regulated kinase 1
chr21_-_35986744 1.998 NM_203417
RCAN1
regulator of calcineurin 1
chr11_-_76380894 1.919 NM_005512
LRRC32
leucine rich repeat containing 32
chr14_+_55221505 1.912 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr3_+_30647901 1.909 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr6_-_134497069 1.898 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_6662898 1.872 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr7_+_100728719 1.865 NM_030961
TRIM56
tripartite motif containing 56
chr3_+_30648372 1.821 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr11_-_2950593 1.813 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr22_-_43343046 1.808 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr11_-_118781612 1.777 NM_182557
BCL9L
B-cell CLL/lymphoma 9-like
chr5_+_179247903 1.774 SQSTM1
sequestosome 1
chr19_+_49376488 1.772 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr2_-_65593866 1.768 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr2_-_175712276 1.731 NM_001206602
CHN1
chimerin (chimaerin) 1
chr2_+_28615771 1.717 NM_005253
FOSL2
FOS-like antigen 2
chr1_-_6662681 1.710 KLHL21
kelch-like 21 (Drosophila)
chr10_-_86001197 1.694 NM_015613
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr6_+_106546736 1.683 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr6_-_138428477 1.648 NM_022121
PERP
PERP, TP53 apoptosis effector
chr3_-_123339178 1.640 MYLK
myosin light chain kinase
chr14_-_24777064 1.638


chr17_-_17399494 1.633 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr7_+_112063131 1.612 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr11_+_128563955 1.609 FLI1
Friend leukemia virus integration 1
chr22_-_45608232 1.603 KIAA0930
KIAA0930
chr6_-_46293628 1.578 NM_005822
RCAN2
regulator of calcineurin 2
chr21_-_35987144 1.562 NM_004414
RCAN1
regulator of calcineurin 1
chr7_+_143078457 1.549 ZYX
zyxin
chr7_+_128095881 1.541 NM_001098786
NM_013332
HILPDA

hypoxia inducible lipid droplet-associated

chr3_-_157221362 1.534 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr11_-_3862137 1.531 RHOG
ras homolog gene family, member G (rho G)
chr5_+_179247911 1.526 SQSTM1
sequestosome 1
chr7_+_48128225 1.518 NM_181597
UPP1
uridine phosphorylase 1
chr6_-_46293404 1.492 RCAN2
regulator of calcineurin 2
chr17_+_7255427 1.476 KCTD11
potassium channel tetramerisation domain containing 11
chr4_-_114900802 1.476 NM_024590
ARSJ
arylsulfatase family, member J
chr15_+_59904090 1.466 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_+_121570630 1.451 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr7_+_143078399 1.447 ZYX
zyxin
chr7_+_143078444 1.446 ZYX
zyxin
chr1_+_156084541 1.444 LMNA
lamin A/C
chr21_-_36421578 1.434 RUNX1
runt-related transcription factor 1
chr5_-_59783885 1.420 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_143078447 1.419 ZYX
zyxin
chr7_+_143078395 1.413 ZYX
zyxin
chr17_+_32582295 1.410 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr3_-_123339423 1.404 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr17_+_30771520 1.402 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_7590731 1.402 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr10_+_104154228 1.385 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr15_+_59903980 1.373 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_+_140868721 1.370 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr13_+_97874704 1.365 MBNL2
muscleblind-like 2 (Drosophila)
chr3_+_105085553 1.361 NM_001243280
NM_001243281
NM_001243283
NM_001627
ALCAM



activated leukocyte cell adhesion molecule



chr7_+_143078358 1.355 NM_001010972
NM_003461
ZYX

zyxin

chr17_+_74261280 1.348 NM_182565
FAM100B
family with sequence similarity 100, member B
chr1_-_27816667 1.343 WASF2
WAS protein family, member 2
chr17_-_34207308 1.338 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr5_+_70944968 1.325 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr19_-_3969734 1.317 NM_001348
DAPK3
death-associated protein kinase 3
chr1_-_244006471 1.280 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_+_150122415 1.278 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr1_-_27816542 1.276 WASF2
WAS protein family, member 2
chr9_+_132934685 1.273 NM_014286
NCS1
neuronal calcium sensor 1
chr5_+_140729723 1.272 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr17_+_74261431 1.270 FAM100B
family with sequence similarity 100, member B
chr1_+_150122095 1.268 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr1_+_150122246 1.264 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr1_+_156084565 1.253 LMNA
lamin A/C
chr6_-_152702450 1.239 SYNE1
spectrin repeat containing, nuclear envelope 1
chr16_+_3115639 1.232 IL32
interleukin 32
chr2_+_36923832 1.231 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr7_+_143058794 1.228 ZYX
zyxin
chr3_+_105085740 1.222 ALCAM
activated leukocyte cell adhesion molecule
chr12_+_56075329 1.214 NM_152637
METTL7B
methyltransferase like 7B
chr14_+_51955854 1.211 NM_001042481
FRMD6
FERM domain containing 6
chr17_-_33390676 1.211 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr1_-_36851484 1.203 NM_032017
STK40
serine/threonine kinase 40
chr6_-_159239269 1.192 NM_003379
EZR
ezrin
chr2_+_28615695 1.183 FOSL2
FOS-like antigen 2
chr6_-_84140854 1.182 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr11_-_51412447 1.174 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr9_+_138453599 1.173 NM_001018049
NM_002571
PAEP

progestagen-associated endometrial protein

chr6_+_26440699 1.170 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr6_-_90062289 1.161 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr6_+_43597278 1.158 NM_001003690
MAD2L1BP
MAD2L1 binding protein
chr1_-_27816676 1.153 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr16_+_67563539 1.150 NM_001193523
FAM65A
family with sequence similarity 65, member A
chr17_-_79881304 1.142 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr6_-_159239198 1.136 EZR
ezrin
chr11_+_35198199 1.120 CD44
CD44 molecule (Indian blood group)
chr3_-_11610264 1.115 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr22_+_20861884 1.112 NM_001003891
NM_015889
MED15

mediator complex subunit 15

chr22_+_20861875 1.108 MED15
mediator complex subunit 15
chr2_+_27719702 1.107 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr9_+_35673852 1.105 NM_001216
CA9
carbonic anhydrase IX
chr12_+_56075418 1.095 METTL7B
methyltransferase like 7B
chr1_-_45308603 1.094 NM_001166292
NM_003738
PTCH2

patched 2

chr1_-_89591685 1.094 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr4_+_81106423 1.091 NM_020226
PRDM8
PR domain containing 8
chr17_-_7493389 1.079 NM_006942
SOX15
SRY (sex determining region Y)-box 15

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 8.87e-06 GO:0050794 regulation of cellular process
1.20 6.28e-05 GO:0050789 regulation of biological process
1.18 7.47e-05 GO:0065007 biological regulation
1.31 3.53e-04 GO:0023052 signaling
1.28 8.25e-04 GO:0051716 cellular response to stimulus
1.31 8.99e-04 GO:0007165 signal transduction
1.34 3.21e-03 GO:0048518 positive regulation of biological process
1.36 4.52e-03 GO:0048522 positive regulation of cellular process
1.36 4.58e-03 GO:0006950 response to stress
1.61 1.11e-02 GO:0009611 response to wounding
1.18 2.77e-02 GO:0050896 response to stimulus
1.51 3.71e-02 GO:0051246 regulation of protein metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 2.91e-05 GO:0005515 protein binding
1.09 6.18e-03 GO:0005488 binding
1.48 4.00e-02 GO:0005102 receptor binding